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HelpTest Code ADIC Disseminated Intravascular Coagulation/Intravascular Coagulation and Fibrinolysis (DIC/ICF) Profile, Plasma
Ordering Guidance
This profile will not detect all bleeding disorders, such as von Willebrand disease. For patients with amyloidosis and bleeding symptoms, obtaining a limited bleeding diathesis profile is suggested.
Multiple coagulation profile tests are available. See Coagulation Profile Comparison for testing that is performed with each profile.
Shipping Instructions
Send the 5 aliquot tubes in the same shipping container.
Necessary Information
Specimen Required
Specimen Type: Platelet-poor plasma
Patient Preparation: Patient should not be receiving warfarin or heparin therapy. If so, note on request.
Collection Container/Tube: Light-blue top (3.2% sodium citrate)
Submission Container/Tube: 5 Plastic vials
Specimen Volume: 5 mL Platelet-poor plasma in 5 plastic vials, each containing 1 mL
Collection Instructions:
1. For complete instructions, see Coagulation Guidelines for Specimen Handling and Processing.
2. Centrifuge, transfer all plasma into a plastic vial, and centrifuge plasma again.
3. Aliquot plasma (1 mL per aliquot) into 5 separate plastic vials, leaving 0.25 mL in the bottom of centrifuged vial.
4. Immediately freeze plasma (no longer than 4 hours after collection) at -20° C or, ideally -40° C or below.
Additional Information: Double-centrifuged specimen is critical for accurate results as platelet contamination may cause spurious results.
Forms
1. Coagulation Patient Information (T675)
2. If not ordering electronically, complete, print, and send a Coagulation Test Request (T753) with the specimen.
Secondary ID
603306Useful For
Establishing laboratory evidence of disseminated intravascular coagulation
Profile Information
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| ADICI | DIC/ICF Prof Interpretation | No | Yes |
| APTSC | Activated Partial Thrombopl Time, P | Yes, (order APTTP) | Yes |
| TTSC | Thrombin Time (Bovine), P | Yes | Yes |
| CLFIB | Fibrinogen, Clauss, P | Yes, (order FIBTP) | Yes |
| DIMER | D-Dimer, P | Yes, (order DDITT) | Yes |
| PTSC | Prothrombin Time (PT), P | Yes, (order PTTP) | Yes |
Reflex Tests
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| RTSC | Reptilase Time, P | Yes | No |
| DRV1 | Dilute Russells Viper Venom Time, P | Yes, (order DRVI1) | No |
| PNP | Platelet Neutralization Procedure | No | No |
| PTMSC | PT Mix 1:1 | No | No |
| APMSC | APTT Mix 1:1 | No | No |
| DRV2 | DRVVT Mix | No | No |
| DRV3 | DRVVT Confirmation | No | No |
| F_2 | Coag Factor II Assay, P | Yes | No |
| FACTV | Coag Factor V Assay, P | Yes | No |
| F_7 | Coag Factor VII Assay, P | Yes | No |
| F8A | Coag Factor VIII Activity Assay, P | Yes | No |
| F_9 | Coag Factor IX Assay, P | No | No |
| F_10 | Coag Factor X Assay, P | Yes | No |
| F_11 | Coag Factor XI Assay, P | Yes | No |
| F_12 | Coag Factor XII Assay, P | Yes | No |
| PTFIB | PT-Fibrinogen, P | Yes | No |
| SOLFM | Soluble Fibrin Monomer | No | No |
| HEXLA | HEX LA, P | No | No |
Testing Algorithm
Initial testing includes prothrombin time (PT), activated partial thromboplastin time (aPTT), thrombin time (TT), fibrinogen, D-dimer, and disseminated intravascular coagulation/intravascular coagulation and fibrinolysis (DIC/ICF) profile interpretation.
If the PT is greater than 13.9 seconds, then the PT mix will be performed at an additional charge.
If the aPTT is 38 seconds or more, then the aPTT mix and dilute Russell's viper venom time (dRVVT) will be performed at an additional charge.
If the dRVVT ratio is 1.20 or more, then the dRVVT mix and dRVVT confirmation will be performed at an additional charge.
If fibrinogen is less than 150 mg/dL, or clinically indicated, then the PT-fibrinogen test will be performed at an additional charge.
If D-dimer is greater than 500 ng/mL fibrinogen equivalent units, then soluble fibrin monomer test will be performed at an additional charge.
If the aPTT mix is 38 or more seconds and the TT is less than 35.0 seconds (no evidence of heparin), then the platelet neutralization procedure will be performed at an additional charge.
If the TT is 25.0 or more seconds, then the reptilase time will be performed at an additional charge.
If appropriate, PT-fibrinogen, coagulation factor assays, or hexagonal lupus anticoagulant testing will be performed, at an additional charge, to clarify a significant abnormality in the screen test results.
Special Instructions
Method Name
PTSC, APTSC, TTSC: Optical Clot-Based
CLFIB: Clauss
DIMER: Latex Immunoassay (LIA)
ADICI: Medical Interpretation
Reporting Name
DIC/ICF ProfSpecimen Type
Plasma Na CitSpecimen Minimum Volume
See Specimen Required
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Plasma Na Cit | Frozen | 14 days |
Reject Due To
| Gross hemolysis | Reject |
| Gross lipemia | Reject |
| Gross icterus | Reject |
Reference Values
An interpretive report is provided.
Day(s) Performed
Monday through Friday
Report Available
1 to 7 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Test Classification
See Individual Test IDsCPT Code Information
85610-PTSC
85730-APTSC
85670-TTSC
85379-DIMER
85384-CLFIB
85390-26-ADICI
85210-Factor II (if appropriate)
85220-Factor V (if appropriate)
85230-Factor VII (if appropriate)
85240-Coagulation factor VIII assay (if appropriate)
85250-Factor IX (if appropriate)
85260-Factor X (if appropriate)
85270-Factor XI (if appropriate)
85280-Factor XII (if appropriate)
85366-Soluble fibrin monomer (if appropriate)
85385-PT-Fibrinogen (if appropriate)
85597-Platelet neutralization for lupus inhibitor (if appropriate)
85598-Hex LA (if appropriate)
85611-PT mix 1:1 (if appropriate)
85613-DRVVT (if appropriate)
85613-DRVVT mix (if appropriate)
85613-DRVVT confirm (if appropriate)
85635-Reptilase time (if appropriate)
85732-APTT mix 1:1 (if appropriate)
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| ADIC | DIC/ICF Prof | 98125-8 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| CLFIB | Fibrinogen, Clauss, P | 48664-7 |
| TTSC | Thrombin Time (Bovine), P | 46717-5 |
| 603323 | Reviewed by | 18771-6 |
| DIMER | D-Dimer, P | In Process |
| APTSC | Activated Partial Thrombopl Time, P | 14979-9 |
| PTSEC | Prothrombin Time (PT), P | 5902-2 |
| INRSC | INR | 6301-6 |
| 603182 | DIC/ICF Prof Interpretation | 69049-5 |